Ketamine provides relief for people previously not helped by psychiatric medications because it has a different method of mechanism than other common medications. For years, the psychiatric world believed that it was a deficiency in the neurotransmitter serotonin that contributed to most forms of anxiety and depression. Most forms of medications for these conditions directly modulate levels of serotonin. Ketamine works on the glutamatergic neurotransmitter system which is why it is a powerful solution for people who did not respond to serotonergic medications. Ketamine allows the brain to increase flexibility in thinking allowing for new, healthier thoughts to replace damaging spirals. Ketamine allows for new neural connections to form which stay even after ketamine is not longer in the body. A major 2022 research paper has dispelled the connection between serotonin and depression and is moving the psychiatric world in the direction ketamine has already initiated.